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Sildenafil Citrate
Sildenafil Citrate is the generic name of the basic drug which is widely used in formulating the branded version known as Viagra presented by the world leader pharmaceutical giants Pfizer Inc. USA. The drug is generally used for the treatment of male erectile dysfunction - impotency or for strengthening the masculine penis for the intended sexual activities. The preliminary competitors of Sildenafil Citrate in the market now are Tadalafil and Vardenafil.

The group of pharmaceutical chemists working at the Sandwich research facility of Pfizer synthesized the compound of Sildenafil Citrate. The compound was originally being studied for its use in the treatment of hypertension – high blood pressure as well as angina pectoris which is one type of ischaemic cardiovascular diseases. However, during the phase I clinical trials headed by Ian Osterloh, recommended that Sildenafil Citrate showed little effect on the angina but instead it could very well attract noticeable penile erections. Thus Pfizer chose to market the drug Sildenafil Citrate for the treatment of erectile dysfunction or impotency instead of using it for the angina treatments.

Viagra is prepared in typical shaped tablet form of blue color in three different strengths of 25mg, 50mg and 100mg. the drug Sildenafil Citrate is being sold only against the specific prescription of the registered medical practitioners, though it was advertised directly on the Television in the United States. There are plenty of websites on the internet nowadays that offer this drug under various schemes. The brand has been so popular that many other producers have launched their products to be known as ‘Herbal Viagra’ in similar shaped and colored tablets only. The drug has several nick names like the vitamin pill or the blue pill etc.

Pfizer Inc. is currently enjoying the worldwide patents for the drug valid until 2011-2013. Sildenafil Citrate is a powerful and selective inhibitor of cGMP specific phosphodiesterase type 5 – PDE5 which is liable for dilapidation of cGMP in the corpus cavernosum. The molecular structure of Sildenafil Citrate is same as cGMP and functions as the competitive binding agent of PDE5 in the corpus cavernosum which causes more cGMP and improved erections in the male penis.

The drug is also considered as metabolized by hepatic enzymes and erected by the liver and kidneys both. The effect of the drug may get delayed if taken with high-fat diets due to the delayed absorption and the highest effect may not be up to the expectations because the plasma concentrations are lowered.

Sildenafil Citrate is reported to show some serious side effects like: Severe hypertension, myocardial infarction, ventricular arrhythmias, priapism, stroke, enhanced intra-ocular pressure and even sudden death. However, the common side effects as noticed or reported may include: sneezing, headaches, flushing, dyspepsia, extended penile erections, palpitations as well as photophobia. The variation in visions may also be experienced like: blurring of vision and bluish tinge as reported in some typical cases. The patients already taking Protease inhibitors for the HIV treatments should be careful as it inhibits the metabolism of Sildenafil and multiplies the plasma levels of Sildenafil, improving the occurrence and seriousness of side effects

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